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Synthesis of Neu5Ac Oligosaccharides and Analogues by Transglycosylation and their Binding Properties as Ligands to MAG
Author(s) -
Neubacher Björn,
Scheid Svenja,
Kelm Sørge,
Frasch Alberto C.,
Meyer Bernd,
Thiem Joachim
Publication year - 2006
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200500543
Subject(s) - chemistry , sialic acid , biochemistry , stereochemistry , epitope , sialidase , trypanosoma cruzi , biology , neuraminidase , enzyme , computer science , antigen , world wide web , parasite hosting , genetics
A trans ‐sialidase from Trypanosoma cruzi was used to prepare several sialic acid‐containing oligosaccharides with a truncated glycerol side chain. STD NMR was used to characterise the binding constant and binding epitope of the oligosaccharides to their neural receptor protein MAG.
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