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How to Control NO Production in Cells: N ω , N ω ‐Dimethyl‐ L ‐Arginine Dimethylaminohydrolase as a Novel Drug Target
Author(s) -
Knipp Markus
Publication year - 2006
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200500527
Subject(s) - arginine , septic shock , regulator , biochemistry , chemistry , biosynthesis , drug , pharmacology , enzyme , biology , sepsis , amino acid , immunology , gene
NO beating . N ω , N ω ‐Dimethyl‐ L ‐arginine dimethylaminohydrolase (DDAH, see Figure) is a regulator of NO production in mammalian organisms. Among the many approaches to inhibit NO production for the treatment of severe diseases like migraine, ischemia, septic shock, or cancer, inhibition of DDAH is a novel and promising one. Research progress in its (patho)physiology and biochemistry is described and discussed in this article.