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Identification of Lipoxygenase Inhibitory Peptides from β‐Casein by Using SPOT Synthesis
Author(s) -
Schurink Marloes,
van Berkel Willem J. H.,
Wichers Harry J.,
Boeriu Carmen G.
Publication year - 2006
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200500461
Subject(s) - lipoxygenase , peptide , chemistry , biochemistry , casein , enzyme
SPOTted by an enzyme . By using SPOT synthesis, peptides from β‐casein that specifically bind to lipoxygenase have been identified. The picture shows binding of fluorescent‐labeled lipoxygenase to the peptide library. Preparative synthesis of some binding peptides and subsequent inhibition assays confirmed a true lipoxygenase inhibition by the octapeptide RINKKIEK.