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Biosynthesis of the Heat‐Shock Protein 90 Inhibitor Geldanamycin: New Insight into the Formation of the Benzoquinone Moiety
Author(s) -
Lee Dongho,
Lee Kyeong,
Cai Xing Fu,
Dat Nguyen Tien,
Boovanahalli Shanthaveerappa K.,
Lee Mijeoung,
Shin Jin Chul,
Kim Woncheol,
Jeong Jae Kap,
Lee Jong Suk,
Lee ChoongHwan,
Lee JeongHyung,
Hong YoungSoo,
Lee Jung Joon
Publication year - 2006
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200500441
Subject(s) - geldanamycin , benzoquinone , moiety , chemistry , hydroquinone , streptomyces hygroscopicus , derivative (finance) , stereochemistry , biosynthesis , heat shock protein , biochemistry , gene , hsp90 , biology , streptomyces , genetics , bacteria , financial economics , economics
A clue towards determining the biosynthetic origin of ansamycin benzoquinone formation by spontaneous oxidation from a corresponding hydroquinone has been provided by ACDL3172 ( 1 ), a tricyclic geldanamycin derivative produced by the gel8 gene‐inactivated strain of S. hygroscopicus subsp. duamyceticus JCM4427.