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Convergent Glycopeptide Synthesis by Traceless Staudinger Ligation and Enzymatic Coupling
Author(s) -
Liu Lei,
Hong ZhangYong,
Wong ChiHuey
Publication year - 2006
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200500437
Subject(s) - glycopeptide , ligation , chemical ligation , chemistry , native chemical ligation , cysteine , combinatorial chemistry , protease , enzyme , biochemistry , peptide , biology , microbiology and biotechnology , antibiotics
Without a trace . An approach combining traceless Staudinger ligation and protease‐catalyzed N‐terminal azidonation has been shown to be efficient for the convergent synthesis of glycopeptides without the cysteine limitation of native chemical ligation.