Miniaturization of Microwave‐Assisted Carbohydrate Functionalization to Create Oligosaccharide Microarrays | Zendy

Brun Matthias A. | Zendy; Disney Matthew D. | Zendy; Seeberger Peter H. | Zendy

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Miniaturization of Microwave‐Assisted Carbohydrate Functionalization to Create Oligosaccharide Microarrays

Author(s) -

Brun Matthias A.,

Disney Matthew D.,

Seeberger Peter H.

Publication year - 2006

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200500361

Subject(s) - glycoconjugate , dna microarray , oligosaccharide , miniaturization , chemistry , carbohydrate , microwave , computational biology , computer science , nanotechnology , biochemistry , biology , materials science , gene expression , gene , telecommunications

A microwave‐assisted Kochetkov reaction (a) has been used on different reducing carbohydrates to obtain glycosylamines and then N ‐iminoglycosylamidines without purification. These glycoconjugates were then used to construct microarrays to test known carbohydrate–protein interactions. This method streamlines efforts required to functionalize carbohydrates for construction of arrays.

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