Selective Staudinger Modification of Proteins Containing  p ‐Azidophenylalanine | Zendy

Tsao MengLin | Zendy; Tian Feng | Zendy; Schultz Peter G. | Zendy

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Selective Staudinger Modification of Proteins Containing p ‐Azidophenylalanine

Author(s) -

Tsao MengLin,

Tian Feng,

Schultz Peter G.

Publication year - 2005

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200500314

Subject(s) - azide , posttranslational modification , mutant , chemistry , peptide , computational biology , combinatorial chemistry , protein engineering , amino acid , biochemistry , biology , gene , organic chemistry , enzyme

The unnatural amino acid p ‐azidophenylalanine was genetically introduced into a phage‐displayed peptide and mutant Z‐domain protein. These azide‐containing proteins were selectively and efficiently modified by using fluorescein‐derived phosphines and the Staudinger ligation reaction (see picture). This work provides a powerful new tool for the selective modification of proteins with a variety of synthetic agents.

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