Premium
Aldolisation of Bis(glycolaldehyde) Phosphate and Formaldehyde
Author(s) -
Smith James M.,
Sutherland John D.
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200500267
Subject(s) - glycolaldehyde , aldol reaction , chemistry , formaldehyde , intramolecular force , organic chemistry , stereochemistry , catalysis
Subtle aldolisation behaviour: An intermolecular aldol reaction between bis(glycolaldehyde) phosphate and formaldehyde does occur (see scheme), but subsequent oligomerisation to the pyranosyl‐RNA backbone is not observed. Instead, intramolecular aldolisation is preferred, and tetrose‐ and pentose‐2,4‐cyclic phosphates are produced in good yield.