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Sunflower‐Shaped Cyclodextrin‐Conjugated Poly(ε‐Lysine) Polyplex as a Controlled Intracellular Trafficking Device
Author(s) -
Choi Hak Soo,
Yamashita Atsushi,
Ooya Tooru,
Yui Nobuhiko,
Akita Hidetaka,
Kogure Kentaro,
Ito Rie,
Harashima Hideyoshi
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200500242
Subject(s) - cyclodextrin , lysine , conjugated system , chemistry , intracellular , transfection , membrane , beta cyclodextrins , biophysics , biochemistry , microbiology and biotechnology , polymer , amino acid , biology , organic chemistry , gene
Lowering your cholesterol . Outward‐facing β‐cyclodextrins in a conjugated poly(ε‐lysine) polyplex (see scheme) promote the removal of cholesterol from the cell membrane; this can induce local membrane disturbances and assist the transfer of pDNA into cells. Furthermore, we propose that the secondary amines of the polyplex promote a proton‐sponge effect to significantly enhance transfection.