Sunflower‐Shaped Cyclodextrin‐Conjugated Poly(ε‐Lysine) Polyplex as a Controlled Intracellular Trafficking Device | Zendy

Choi Hak Soo | Zendy; Yamashita Atsushi | Zendy; Ooya Tooru | Zendy; Yui Nobuhiko | Zendy; Akita Hidetaka | Zendy; Kogure Kentaro | Zendy; Ito Rie | Zendy; Harashima Hideyoshi | Zendy

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Sunflower‐Shaped Cyclodextrin‐Conjugated Poly(ε‐Lysine) Polyplex as a Controlled Intracellular Trafficking Device

Author(s) -

Choi Hak Soo,

Yamashita Atsushi,

Ooya Tooru,

Yui Nobuhiko,

Akita Hidetaka,

Kogure Kentaro,

Ito Rie,

Harashima Hideyoshi

Publication year - 2005

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200500242

Subject(s) - cyclodextrin , lysine , conjugated system , chemistry , intracellular , transfection , membrane , beta cyclodextrins , biophysics , biochemistry , microbiology and biotechnology , polymer , amino acid , biology , organic chemistry , gene

Lowering your cholesterol . Outward‐facing β‐cyclodextrins in a conjugated poly(ε‐lysine) polyplex (see scheme) promote the removal of cholesterol from the cell membrane; this can induce local membrane disturbances and assist the transfer of pDNA into cells. Furthermore, we propose that the secondary amines of the polyplex promote a proton‐sponge effect to significantly enhance transfection.

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