Carbon Nanotube Delivery of the GFP Gene into Mammalian Cells | Zendy

Gao Lizeng | Zendy; Nie Leng | Zendy; Wang Taihong | Zendy; Qin Yujun | Zendy; Guo Zhixin | Zendy; Yang Dongling | Zendy; Yan Xiyun | Zendy

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Carbon Nanotube Delivery of the GFP Gene into Mammalian Cells

Author(s) -

Gao Lizeng,

Nie Leng,

Wang Taihong,

Qin Yujun,

Guo Zhixin,

Yang Dongling,

Yan Xiyun

Publication year - 2006

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200500227

Subject(s) - green fluorescent protein , gene delivery , carbon nanotube , cytotoxicity , dna , nanotechnology , gene , biophysics , chemistry , fluorescence , microbiology and biotechnology , genetic enhancement , materials science , biochemistry , biology , in vitro , physics , quantum mechanics

Special delivery. Amino‐functionalized multiwalled carbon nanotubes (NH 2 ‐MWCNTs) were found to interact with negatively charged DNA and the cell membrane (see figure). Through this interaction, NH 2 ‐MWCNTs successfully delivered the GFP (green fluorescent protein) gene into mammalian cells without any cytotoxicity. The results show that NH 2 ‐MWCNT is a novel gene carrier and has potential application in gene delivery.

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