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A Novel Method to Synthesize Versatile Multiple‐Branched DNA (MB‐DNA) by Reversible Photochemical Ligation
Author(s) -
Ogasawara Shinzi,
Fujimoto Kenzo
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200500188
Subject(s) - dna , dna computing , midstream , ligation , computer science , chemistry , biophysics , computational biology , nanotechnology , biology , microbiology and biotechnology , materials science , biochemistry , fossil fuel , organic chemistry
Branching out into the nano world . We have demonstrated that DNA containing 5‐carboxyvinyldeoxyuridine ( CV U) at midstream can be used to synthesize multiple‐branched DNA with high efficiency by irradiation at 366 nm (see scheme). This novel method is well suited to DNA nanodevices such as the DNA walker, DNA computer, and DNA architecture, as well as to signal amplification.