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Synthesis and Properties of Aminopropyl Nucleic Acids
Author(s) -
Zhou Ding,
Lagoja Irene M.,
Rozenski Jef,
Busson Roger,
Van Aerschot Arthur,
Herdewijn Piet
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200500170
Subject(s) - nucleic acid , chemistry , combinatorial chemistry , biochemistry , computational biology , nanotechnology , biology , materials science
Oligonucleotides that contain up to three aminopropyl nucleoside analogues have been synthesized. Dimers of aminopropyl adenine and thymidine were prepared and used as building blocks by applying phosphoramidite chemistry. Both R and S isomers of the aminopropyl nucleosides were used. This incorporation led to a reduction of thermal stability of double‐stranded DNA. Furthermore, the ( R )‐adenine analogue, which yielded ( S )‐APNA, can be considered as a candidate for universal base pairing.