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The RAD6 Pathway: Control of DNA Damage Bypass and Mutagenesis by Ubiquitin and SUMO
Author(s) -
Ulrich Helle D.
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200500139
Subject(s) - dna damage , ubiquitin , dna replication , mutagenesis , biology , postreplication repair , dna repair , microbiology and biotechnology , proliferating cell nuclear antigen , replication (statistics) , dna , genetics , eukaryotic dna replication , regulator , mutation , nucleotide excision repair , gene , virology
Tolerance mechanisms against DNA damage allow cells to complete DNA replication in the presence of lesions that would otherwise inhibit the progression of the replication fork. As these bypass systems often operate with reduced fidelity, a tight control over their activity is required to prevent the accumulation of unwanted mutations. In eukaryotes, control of damage tolerance is exerted by the modification of PCNA, an essential regulator of the replication fork, by the small proteins ubiquitin and SUMO.