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Artificial Transcriptional Activation Domains
Author(s) -
Lum Jenifer K.,
Mapp Anna K.
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200500036
Subject(s) - computational biology , chemistry , nanotechnology , biology , microbiology and biotechnology , materials science
Artificial transcriptional activators show great promise as tools to probe activator function as well as provide a basis for future transcription‐based therapeutics. This review highlights the current methods used to isolate artificial activation domains as well as novel peptidic and small‐molecule activation domains recently identified. Considerations and challenges in artificial activator design will also be discussed.