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Dynamics‐Based Amplification of RNA Function and Its Characterization by Using NMR Spectroscopy
Author(s) -
AlHashimi Hashim M.
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200500002
Subject(s) - rna , function (biology) , nucleic acid structure , dynamics (music) , nuclear magnetic resonance spectroscopy , functional diversity , molecular dynamics , characterization (materials science) , chemistry , biopolymer , biophysics , nucleotide , computational biology , biological system , nanotechnology , computational chemistry , biology , biochemistry , stereochemistry , materials science , physics , microbiology and biotechnology , polymer , gene , organic chemistry , ecology , acoustics
The ever‐increasing cellular roles ascribed to RNA raise fundamental questions regarding how a biopolymer composed of only four chemically similar building‐block nucleotides achieves such functional diversity. Here, I discuss how RNA achieves added mechanistic and chemical complexity by undergoing highly controlled conformational changes in response to a variety of cellular signals. I examine pathways for achieving selectivity in these conformational changes that rely to different extents on the structure and dynamics of RNA. Finally, I review solution‐state NMR techniques that can be used to characterize RNA structural dynamics and its relationship to function.