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Cover Picture: Locked Nucleic Acids and Intercalating Nucleic Acids in the Design of Easily Denaturing Nucleic Acids: Thermal Stability Studies (ChemBioChem 12/2004)
Author(s) -
Filichev Vyacheslav V.,
Christensen Ulf B.,
Pedersen Erik B.,
Babu B. Ravindra,
Wengel Jesper
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200490045
Subject(s) - nucleic acid , dna , intercalation (chemistry) , chemistry , nucleic acid structure , thermal stability , nucleic acid quantitation , nucleic acid analogue , nucleic acid thermodynamics , biochemistry , combinatorial chemistry , rna , organic chemistry , base sequence , gene
The cover picture shows fully modified locked nucleic acids (LNAs, orange) and intercalating nucleic acids (INAs®, red) with several insertions of ( R )‐1‐ O ‐(1‐pyrenylmethyl)glycerol, both displaying higher binding affinity to native DNA (white) than to each other. In their full paper on p. 1673 ff, E. B. Pedersen et al. describe the design of easily denaturing nucleic acid duplexes using complementary LNAs and INAs, and how the combined use of these chemically modified nucleic acids can solve the problem of "quenching" due to complementary strands of duplexes or hairpins that otherwise limit their use for DNA targeting.