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Cover Picture: Dendritic Polyamines: Simple Access to New Materials with Defined Treelike Structures for Application in Nonviral Gene Delivery (ChemBioChem 8/2004)
Author(s) -
Krämer Michael,
Stumbé JeanFrançois,
Grimm Günther,
Kaufmann Brigitte,
Krüger Ute,
Weber Martin,
Haag Rainer
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200490031
Subject(s) - transfection , gene delivery , branching (polymer chemistry) , in vitro , dna , chemistry , nanotechnology , gene , microbiology and biotechnology , biophysics , biology , biochemistry , materials science , organic chemistry
The cover picture shows the highly branched dendritic polymers obtained from controlled conversion of hyperbranched polyethyleneimine (PEI) by addition of acrylonitrile and subsequent reduction. These PEI–PPI (polypropylenimine) dendritic architectures have been tested for their in vitro DNA‐transfection efficiencies in various cell lines. Surprisingly, not only the molecular‐weight screening but also the precise tailoring of different degrees of branching show clear transfection maxima. The background shows the transfected cells in blue as observed in the galactosidase assay. Detailed information about these highly active nonviral vectors for in vitro DNA delivery is reported by R. Haag et al. on p. 1081 ff.