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Benzofuroindole Analogues as Potent BK Ca Channel Openers
Author(s) -
Gormemis Ahmet E.,
Ha Tal Soo,
Im Isak,
Jung KwanYoung,
Lee Ju Yeon,
Park ChulSeung,
Kim YongChul
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400448
Subject(s) - bk channel , potassium channel , calcium activated potassium channel , pharmacology , chemistry , calcium channel , calcium , neuroscience , medicine , biology , organic chemistry
Toward drugs to treat neuronal damage . The design and synthesis of new, potent, large‐conductance, calcium‐activated potassium‐channel (BK Ca ) openers that show calcium‐independent activation in electrophysiological evaluations have been brought about through optimizing the structure of the benzofuroindole skeleton by comparison with a known BK Ca ‐channel opener (BMS‐204352; see scheme). These new channel openers might find therapeutic use in stroke, asthma, hypertension, convulsion, and traumatic brain injury.