High‐Throughput Evaluation of Antioxidant and Pro‐oxidant Activities of Polyphenols with Thymidine Protection Assays | Zendy

Meunier Stéphane | Zendy; Hanédanian Mikaël | Zendy; DesageEl Murr Marine | Zendy; Nowaczyk Stéphanie | Zendy; Le Gall Thierry | Zendy; Pin Serge | Zendy; Renault JeanPhilippe | Zendy; Boquet Didier | Zendy; Crémi Christophe | Zendy; Mioskowski Charles | Zendy; Taran Frédéric | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

High‐Throughput Evaluation of Antioxidant and Pro‐oxidant Activities of Polyphenols with Thymidine Protection Assays

Author(s) -

Meunier Stéphane,

Hanédanian Mikaël,

DesageEl Murr Marine,

Nowaczyk Stéphanie,

Le Gall Thierry,

Pin Serge,

Renault JeanPhilippe,

Boquet Didier,

Crémi Christophe,

Mioskowski Charles,

Taran Frédéric

Publication year - 2005

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200400421

Subject(s) - pro oxidant , antioxidant , chemistry , radiolysis , thymidine , oxidative stress , high throughput screening , polyphenol , combinatorial chemistry , biochemistry , oxidative phosphorylation , radical , dna

A recently reported high‐throughput screening strategy has been applied to the rapid selection of new water‐soluble antioxidants that display strong protective activities. Based on a competitive immunoassay, a triple‐screening procedure was used to evaluate the ability of different compounds to protect thymidine under different oxidative stresses. The pro‐oxidant effect of norbadione A in the presence of iron was observed, while some pulvinic acid derivatives proved strongly protective during γ radiolysis, UV irradiation, and Fenton‐like oxidation.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research