Potent and Selective Inhibition of Class II α‐ D ‐Mannosidase Activity by a Bicyclic Sulfonium Salt | Zendy

Siriwardena Aloysius | Zendy; Strachan Heather | Zendy; ElDaher Samer | Zendy; Way Gemma | Zendy; Winchester Bryan | Zendy; Glushka John | Zendy; Moremen Kelley | Zendy; Boons GeertJan | Zendy

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Potent and Selective Inhibition of Class II α‐ D ‐Mannosidase Activity by a Bicyclic Sulfonium Salt

Author(s) -

Siriwardena Aloysius,

Strachan Heather,

ElDaher Samer,

Way Gemma,

Winchester Bryan,

Glushka John,

Moremen Kelley,

Boons GeertJan

Publication year - 2005

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200400397

Subject(s) - sulfonium , swainsonine , chemistry , glycoside hydrolase , mannosidase , stereochemistry , biochemistry , bicyclic molecule , salt (chemistry) , combinatorial chemistry , computational biology , enzyme , biology , organic chemistry

Salted away . Shortcomings in the potency and selectivity of natural glycosidase inhibitors, such as swainsonine ( 1 ), have led to the proposal of a host of alternative synthetic structural motifs. This paper reports the synthesis of the polyhydroxylated sulfonium salt 2 and demonstrates it to be a potent inhibitor of various human class II α‐ D ‐mannosidase activities.

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