A Homologue of the  Mycobacterium tuberculosis  PapA5 Protein, Rif‐Orf20, Is an Acetyltransferase Involved in the Biosynthesis of Antitubercular Drug Rifamycin B by  Amycolatopsis mediterranei  S699 | Zendy

Xiong Yeping | Zendy; Wu Xiumei | Zendy; Mahmud Taifo | Zendy

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A Homologue of the Mycobacterium tuberculosis PapA5 Protein, Rif‐Orf20, Is an Acetyltransferase Involved in the Biosynthesis of Antitubercular Drug Rifamycin B by Amycolatopsis mediterranei S699

Author(s) -

Xiong Yeping,

Wu Xiumei,

Mahmud Taifo

Publication year - 2005

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200400387

Subject(s) - rifamycin , acetyltransferase , biosynthesis , mycobacterium tuberculosis , acyltransferases , enzyme , biochemistry , chemistry , stereochemistry , tuberculosis , biology , microbiology and biotechnology , antibiotics , medicine , gene , pathology , acetylation

Toward antitubercular drugs . Rif‐Orf20, a homologue of M. tuberculosis PapA5 protein, is an acetyltransferase that is responsible for the conversion of DMDARSV to DMRSV in rifamycin B biosynthesis. This enzyme, together with PapA5, represents a new class of acyltransferases. The enzyme also utilizes propionyl‐CoA as substrate to give rise to a new analogue of rifamycin that appears, from spectroscopic results, to have the structure 1 .

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