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Rapid and Quantitative Cyclization of Multiple Peptide Loops onto Synthetic Scaffolds for Structural Mimicry of Protein Surfaces
Author(s) -
Timmerman Peter,
Beld Joris,
Puijk Wouter C.,
Meloen Rob H.
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400374
Subject(s) - mimicry , peptide , chemistry , combinatorial chemistry , cysteine , side chain , molecular mimicry , click chemistry , stereochemistry , biophysics , organic chemistry , biochemistry , biology , ecology , genetics , antigen , enzyme , polymer
No need for side‐chain protection in the cyclization reaction of cysteine‐containing linear peptides onto bromomethylated aromatic scaffolds (see scheme). The reaction is extremely fast and clean and runs to completion in less than 15 min at room temperature.