Remarkable Stabilization of Duplex DNA Containing an Abasic Site by Non‐Nucleosidic Phenanthroline and Pyrene Building Blocks | Zendy

Langenegger Simon M. | Zendy; Häner Robert | Zendy

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Remarkable Stabilization of Duplex DNA Containing an Abasic Site by Non‐Nucleosidic Phenanthroline and Pyrene Building Blocks

Author(s) -

Langenegger Simon M.,

Häner Robert

Publication year - 2005

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200400370

Subject(s) - phenanthroline , ap site , nucleobase , duplex (building) , dna , pyrene , chemistry , combinatorial chemistry , dna damage , stereochemistry , biochemistry , crystallography , organic chemistry

Filling the gap . Abasic sites represent a frequently occurring lesion in DNA. If not repaired, such lesions can lead to mutations or cell death. Stabilization of DNA containing abasic sites is investigated as a therapeutic approach for the treatment of cancer. Non‐nucleosidic phenanthroline and pyrene derivatives were found to have a profound stabilizing effect (Δ T m =8 °C) on DNA missing a nucleobase.

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