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Remarkable Stabilization of Duplex DNA Containing an Abasic Site by Non‐Nucleosidic Phenanthroline and Pyrene Building Blocks
Author(s) -
Langenegger Simon M.,
Häner Robert
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400370
Subject(s) - phenanthroline , ap site , nucleobase , duplex (building) , dna , pyrene , chemistry , combinatorial chemistry , dna damage , stereochemistry , biochemistry , crystallography , organic chemistry
Filling the gap . Abasic sites represent a frequently occurring lesion in DNA. If not repaired, such lesions can lead to mutations or cell death. Stabilization of DNA containing abasic sites is investigated as a therapeutic approach for the treatment of cancer. Non‐nucleosidic phenanthroline and pyrene derivatives were found to have a profound stabilizing effect (Δ T m =8 °C) on DNA missing a nucleobase.