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New Insights for Pursuing High Relaxivity MRI Agents from Modelling the Binding Interaction of Gd III Chelates to HSA
Author(s) -
Aime Silvio,
Gianolio Eliana,
Longo Dario,
Pagliarin Roberto,
Lovazzano Clara,
Sisti Massimo
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400364
Subject(s) - moiety , chelation , chemistry , adduct , small molecule , molecule , protein–protein interaction , combinatorial chemistry , stereochemistry , nanotechnology , biochemistry , organic chemistry , materials science
Sticking out . This work is aimed at obtaining new insights into the design of novel Gd chelates that form high‐affinity adducts with HSA. Two new Gd III complexes that differ in the size of the hydrophobic moiety responsible for the interaction with the protein have been synthesised. It was shown that the two complexes protrude to a different extent from the surface of the protein (see picture), and this difference has an effect on the exchange of the coordinated water molecule.