Premium
Design, Synthesis and Antimalarial Activity of Trifluoromethylartemisinin–Mefloquine Dual Molecules
Author(s) -
Grellepois Fabienne,
Grellier Philippe,
BonnetDelpon Danièle,
Bégué JeanPierre
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400347
Subject(s) - mefloquine , dual (grammatical number) , malaria , plasmodium falciparum , combinatorial chemistry , chemistry , pharmacology , stereochemistry , biology , immunology , philosophy , linguistics
Caught in the ACT . Two novel antimalarial molecules combining a CF 3 ‐artemisinin derivative (blue) and mefloquine (pink) have been synthesized. In vitro and in vivo assays of this artemisinin‐based combination therapy (ACT) showed the high efficacy of both chimeras against Plasmodium falciparum.