Premium
Synthesis of Diazirinyl Photoprobe Carrying a Novel Cleavable Biotin
Author(s) -
Park Jongjip,
Sadakane Yutaka,
Masuda Katsuyoshi,
Tomohiro Takenori,
Nakano Taku,
Hatanaka Yasumaru
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400342
Subject(s) - biotinylation , biotin , photoaffinity labeling , chemistry , biochemistry , combinatorial chemistry , receptor
Rapid screening of receptor proteins is possible through the development of novel cleavable biotinylated photoaffinity probes that bear an acylsulfonamide linkage. The method purified photoaffinity biotinylated proteins by simple sequential steps without significant levels of contamination.