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New Allosteric Modulators of Metabotropic Glutamate Receptor 5 (mGluR5) Found by Ligand‐Based Virtual Screening
Author(s) -
Renner Steffen,
Noeske Tobias,
Parsons Christopher G.,
Schneider Petra,
Weil Tanja,
Schneider Gisbert
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400332
Subject(s) - metabotropic glutamate receptor 5 , virtual screening , pharmacophore , allosteric regulation , metabotropic glutamate receptor 2 , metabotropic glutamate receptor , metabotropic glutamate receptor 7 , metabotropic glutamate receptor 1 , chemistry , metabotropic glutamate receptor 3 , ligand (biochemistry) , metabotropic glutamate receptor 4 , computational biology , computer science , glutamate receptor , receptor , biochemistry , biology
Ligand‐based pharmacophore searching identified new allosteric modulators of metabotropic glutamate receptor 5 (mGluR5), a class III G protein‐coupled receptor. This virtual‐screening approach can be seen as a working alternative to more demanding structure‐based design techniques with the main aim of developing novel lead series.