Elucidation of the Glycosylation Sequence of Mithramycin Biosynthesis: Isolation of 3A‐Deolivosylpremithramycin B and Its Conversion to Premithramycin B by Glycosyltransferase MtmGII | Zendy

NureAlam Mohammad | Zendy; Méndez Carmen | Zendy; Salas José A. | Zendy; Rohr Jürgen | Zendy

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Elucidation of the Glycosylation Sequence of Mithramycin Biosynthesis: Isolation of 3A‐Deolivosylpremithramycin B and Its Conversion to Premithramycin B by Glycosyltransferase MtmGII

Author(s) -

NureAlam Mohammad,

Méndez Carmen,

Salas José A.,

Rohr Jürgen

Publication year - 2005

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200400309

Subject(s) - glycosyltransferase , glycosylation , biosynthesis , mutant , biochemistry , isolation (microbiology) , chemistry , sequence (biology) , biology , enzyme , gene , bioinformatics

The last step at last . The isolation and structure elucidation of the novel premithramycin‐type compound 3A‐deolivosylpremithramycin B ( 1 ) allowed cross‐feeding experiments with this compound to two glycosyltransferase‐minus mutants of the mithramycin producer S. argillaceus ; this has solved the sequence of the last glycosylation steps of mithramycin biosynthesis.

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