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DNA Interstrand Crosslinks: Natural and Drug‐Induced DNA Adducts that Induce Unique Cellular Responses
Author(s) -
Schärer Orlando D.
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400287
Subject(s) - dna , chemistry , cytotoxic t cell , drug , adduct , dna synthesis , dna damage , drug discovery , biochemistry , combinatorial chemistry , computational biology , biology , pharmacology , in vitro , organic chemistry
Tied down . DNA interstrand crosslinks are cytotoxic adducts formed naturally and by drugs used in antitumor therapy. Our current knowledge of the cellular responses induced by crosslinks and new methods for the synthesis of crosslinks developed to study the biological responses they induce are reviewed.