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A Widely Distributed Bacterial Pathway for Siderophore Biosynthesis Independent of Nonribosomal Peptide Synthetases
Author(s) -
Challis Gregory L.
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400283
Subject(s) - nonribosomal peptide , siderophore , biology , biosynthesis , peptide , biochemistry , computational biology , bacteria , chemistry , microbiology and biotechnology , enzyme , genetics
Catch Fe if you can . Many siderophores are peptides biosynthesised by the well‐studied nonribosomal peptide synthetase (NRPS) multienzyme family. However, recent research has demonstrated that several siderophores, for example desferrioxamine E, are assembled via an NRPS‐independent siderophore (NIS) pathway. In this minireview, research progress to date on the NIS pathway is summarised, and the distribution and mechanistic rationalisations of the pathway are analysed.