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Chemical Approaches to Controlling Intracellular Protein Degradation
Author(s) -
Schneekloth John S.,
Crews Craig M.
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400274
Subject(s) - proteolysis , computational biology , protein degradation , intracellular , chemistry , chemical biology , biology , biochemistry , enzyme
Inactive . Recent advances have yielded many ways to study proteins by means of inactivation. Traditional methods of genetic knockout are complimented by newer techniques, including RNAi and small molecules that induce proteolysis (see scheme). Although seemingly in competition, these techniques each offer solutions to specific problems in proteomic analysis.