Extended Target Sequence Specificity of PNA–Minor‐Groove Binder Conjugates | Zendy

Nielsen Peter E. | Zendy; Frederiksen Karin | Zendy; Behrens Carsten | Zendy

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Extended Target Sequence Specificity of PNA–Minor‐Groove Binder Conjugates

Author(s) -

Nielsen Peter E.,

Frederiksen Karin,

Behrens Carsten

Publication year - 2005

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200400251

Subject(s) - conjugate , minor groove , moiety , sequence (biology) , dna , peptide nucleic acid , chemistry , peptide , stereochemistry , nucleic acid , groove (engineering) , combinatorial chemistry , biochemistry , materials science , mathematical analysis , mathematics , metallurgy

Conjugal bliss . We show that a peptide nucleic acid–Hoechst conjugate (see scheme) kinetically and sequence preferentially guides the PNA moiety to target a binding site proximal to an A–T region that has an affinity for the minor‐groove binder. These results demonstrate a new strategy for constructing DNA recognition ligands composed of a sequence‐guiding domain that increases the target specificity and a DNA‐modification domain that determines the biological activity of the conjugate.

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