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A Biomimetic Model of Tandem Radical Damage Involving Sulfur‐Containing Proteins and Unsaturated Lipids
Author(s) -
Ferreri Carla,
Manco Immacolata,
FaraoneMennella M. Rosaria,
Torreggiani Armida,
Tamba Maurizio,
Chatgilialoglu Chryssostomos
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400250
Subject(s) - chemistry , radical , lipid bilayer , vesicle , tandem , sulfur , fatty acid , methionine , organic chemistry , biochemistry , amino acid , membrane , materials science , composite material
A radical change . γ irradiation of a DOPC ( cis lipid) vesicle suspension containing RNase A shows protein degradation with formation of DEPC ( trans lipid). Thiyl radicals are the isomerizing agents, deriving from the degradation of methionine residues, which are formed in the water compartment and diffuse in the lipid bilayer, converting the cis fatty acid residues to the trans isomers.