Premium
Small‐Molecule Inhibitors and Probes for Ubiquitin‐ and Ubiquitin‐Like‐Specific Proteases
Author(s) -
Borodovsky Anna,
Ovaa Huib,
Meester Wim J. N.,
Venanzi Emily S.,
Bogyo Matthew S.,
Hekking Brian G.,
Ploegh Hidde L.,
Kessler Benedikt M.,
Overkleeft Herman S.
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400236
Subject(s) - ubiquitin , proteases , deubiquitinating enzyme , small molecule , chemistry , biochemistry , protein degradation , linker , microbiology and biotechnology , computational biology , enzyme , biology , gene , computer science , operating system
There's always a catch . The post‐translational modification of proteins with ubiquitin (Ub) or ubiquitin‐like (Ubl) modifiers is an important signal in the regulation of a variety of biological processes, such as degradation and regulation of gene expression. Here we report the synthesis of a panel of peptide vinyl sulfones (see scheme) harboring various portions of the Ub C terminus by using a safety‐catch linker. Depending on their length, such compounds can efficiently target Ubl‐specific proteases.