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Aminoglycoside‐Hybrid Ligands Targeting the Ribosomal Decoding Site
Author(s) -
Vourloumis Dionisios,
Winters Geoffrey C.,
Simonsen Klaus B.,
Takahashi Masayuki,
Ayida Benjamin K.,
Shandrick Sarah,
Zhao Qiang,
Han Qing,
Hermann Thomas
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400197
Subject(s) - neomycin , aminoglycoside , ribosome , sisomicin , chemistry , ribosomal rna , protein subunit , protein biosynthesis , binding site , translation (biology) , biology , rna , computational biology , biochemistry , antibiotics , gentamicin , gene , messenger rna , tobramycin
Bacterial bridges : RNA helix 44 within the small subunit of the bacterial ribosome is the target for natural aminoglycoside antibiotics of the neomycin and hygromycin classes, which bind at neighboring sites and thereby interfere with protein synthesis. We describe synthetic aminoglycoside‐hybrid ligands, such as 1 , designed to inhibit translation by bridging between the neamine and hygromycin binding sites.