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Inhibition of Angiogenesis‐Relevant Receptor Tyrosine Kinases by Sulindac Analogues
Author(s) -
Gourzoulidou Eleni,
Carpintero Mercedes,
Baumhof Patrick,
Giannis Athanassios,
Waldmann Herbert
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400192
Subject(s) - sulindac , receptor tyrosine kinase , angiogenesis , chemistry , tyrosine kinase , kinase , pharmacology , receptor , receptor protein tyrosine kinases , biochemistry , cancer research , biology , nonsteroidal
It's in the blood . Analogues (see formula) of the non‐steroidal inflammatory drug Sulindac are potent and selective inhibitors of the angiogenesis‐related receptor tyrosine kinases VEGFR‐2 and ‐3, IGF1R, FGF1R and Tie‐2; this suggests a possible link between the antiangiogenic properties of Sulindac metabolites and kinase inhibition.