Premium
Relevance of Atypical Protein Kinase C Isotypes to the Drug Discovery Process
Author(s) -
Jenny Marcel,
Wrulich Oliver A.,
Schwaiger Wolfgang,
Ueberall Florian
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400186
Subject(s) - drug discovery , protein kinase domain , protein kinase a , kinase , apoptosis , cell growth , biology , microbiology and biotechnology , programmed cell death , drug , computational biology , chemistry , biochemistry , gene , pharmacology , mutant
Cell proliferation and cell death in tumours are molecular mechanisms that underlie the interplay of proliferation and apoptosis. Atypical protein kinase C isotypes possess a so‐called OPCA motif with novel regulatory domain characteristics potentially exploitable for antitumour pharmaceutical intervention.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom