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Relevance of Atypical Protein Kinase C Isotypes to the Drug Discovery Process
Author(s) -
Jenny Marcel,
Wrulich Oliver A.,
Schwaiger Wolfgang,
Ueberall Florian
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400186
Subject(s) - drug discovery , protein kinase domain , protein kinase a , kinase , apoptosis , cell growth , biology , microbiology and biotechnology , programmed cell death , drug , computational biology , chemistry , biochemistry , gene , pharmacology , mutant
Cell proliferation and cell death in tumours are molecular mechanisms that underlie the interplay of proliferation and apoptosis. Atypical protein kinase C isotypes possess a so‐called OPCA motif with novel regulatory domain characteristics potentially exploitable for antitumour pharmaceutical intervention.