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The Target Discovery Process
Author(s) -
Egner Ursula,
Krätzschmar Jörn,
Kreft Bertolt,
Pohlenz HansDieter,
Schneider Martin
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400158
Subject(s) - drug discovery , computer science , identification (biology) , business process discovery , process (computing) , lead (geology) , computational biology , selection (genetic algorithm) , biochemical engineering , risk analysis (engineering) , machine learning , bioinformatics , biology , engineering , work in process , medicine , paleontology , operations management , botany , business process modeling , operating system , business process
In order to minimise attrition rates in drug development projects, a target discovery process is implemented to select and characterise the most suitable candidate kinase targets, before lead identification and lead optimisation are embarked upon. The process consists of 1) target selection, 2) target assessment, and 3) target validation. This rational approach to target discovery, as a prerequisite for lead discovery, ensures that new therapeutic targets fulfil a set of general criteria, as well as indication‐specific, descriptive and functional ones. The approach should ultimately maximise the likelihood of achieving target‐selective inhibition by small‐molecule inhibitors with minimal in vivo side effects and a therapeutic effect based on a sound biological hypothesis.