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The Core Structures of Roseophilin and the Prodigiosin Alkaloids Define a New Class of Protein Tyrosine Phosphatase Inhibitors
Author(s) -
Fürstner Alois,
Reinecke Kerstin,
Prinz Heino,
Waldmann Herbert
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400135
Subject(s) - prodigiosin , protein tyrosine phosphatase , phosphatase , protein phosphatase 2 , biochemistry , dual specificity phosphatase , tyrosine , dusp6 , chemistry , biology , enzyme , gene , escherichia coli , serratia marcescens
A common core . Protein phosphatases, such as the dual‐specificity phosphatase VHR and the tyrosine phosphatase PTP1B, are key regulators of innumerable cellular processes, and new classes of phosphatase inhibitors are in demand. The azafulvene‐containing core structures of the roseophilin and prodigiosin alkaloids define such a new class.