Function of  lanGT3 , a Glycosyltransferase Gene Involved in Landomycin A Biosynthesis | Zendy

Luzhetskyy Andriy | Zendy; Liu Tao | Zendy; Fedoryshyn Marta | Zendy; Ostash Bohdan | Zendy; Fedorenko Viktor | Zendy; Rohr Jürgen | Zendy; Bechthold Andreas | Zendy

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Function of lanGT3 , a Glycosyltransferase Gene Involved in Landomycin A Biosynthesis

Author(s) -

Luzhetskyy Andriy,

Liu Tao,

Fedoryshyn Marta,

Ostash Bohdan,

Fedorenko Viktor,

Rohr Jürgen,

Bechthold Andreas

Publication year - 2004

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200400123

Subject(s) - glycosyltransferase , biosynthesis , mutant , polyketide , gene , biochemistry , trisaccharide , function (biology) , biology , chemistry , genetics

The glycosyltransferase gene lanGT3 , involved in the biosynthesis of the angucyclic antibiotic landomycin A, has been characterised by targeted gene deletion. A lanGT3 mutant was shown to produce landomycin E, which consists of a trisaccharide side chain attached to the polyketide moiety. Expression of lanGT3 in the mutant restored landomycin A production. Our results indicate that LanGT3 is responsible for the transfer of the fourth sugar during landomycin A biosynthesis.

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