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Target‐Family‐Oriented Focused Libraries for Kinases—Conceptual Design Aspects and Commercial Availability
Author(s) -
Prien Olaf
Publication year - 2005
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400117
Subject(s) - kinase , drug discovery , protein serine threonine kinases , computer science , biology , bioinformatics , biochemistry , protein kinase a
Tailor‐made libraries may increase the likelihood of identifying potential lead candidates in early drug‐discovery phases. That at least 12 commercial vendors offer their services in providing compound collections of tentative kinase inhibitors reflects the growing interest in kinases within the pharmaceutical industry. Some conceptual design approaches for focused library design for the kinase family are reviewed, and the design concepts of these commercialized libraries is discussed.