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Enhancing Membrane Permeability by Fatty Acylation of Oligoarginine Peptides
Author(s) -
Pham Wellington,
Kircher Moritz F.,
Weissleder Ralph,
Tung ChingHsuan
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400063
Subject(s) - cytoplasm , moiety , acylation , chemistry , drug delivery , peptide , biochemistry , computational biology , stereochemistry , organic chemistry , biology , catalysis
A systematic study of fatty acylated polyarginines as drug‐delivery modules is described. A remarkable uptake was observed when a myristate moiety was incorporated with a 7‐mer polyarginine (see scheme). Microscopic studies suggest that the fatty acylated peptide is internalized into the cytoplasm, not the nucleus, thus providing an alternative method for drug delivery.