Use of “Tethering” for the Identification of a Small Molecule that Binds to a Dynamic Hot Spot on the Interleukin‐2 Surface | Zendy

Berg Thorsten | Zendy

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Use of “Tethering” for the Identification of a Small Molecule that Binds to a Dynamic Hot Spot on the Interleukin‐2 Surface

Author(s) -

Berg Thorsten

Publication year - 2004

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200400054

Subject(s) - tethering , small molecule , chemistry , biophysics , hot spot (computer programming) , surface protein , microbiology and biotechnology , nanotechnology , biochemistry , biology , computer science , materials science , virology , operating system

Get into the groove . Despite the absence of an obvious binding pocket in the surface of interleukin‐2, a small molecule has been discovered that “digs” itself into the protein surface and thereby inhibits an important protein–protein interaction. This Highlight discusses the discovery of the inhibitor by a fragment‐assembly method referred to as “tethering”. (Graphic reprinted with permission from ref. [4]. Copyright 2003 American Chemical Society)

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