Premium
Use of “Tethering” for the Identification of a Small Molecule that Binds to a Dynamic Hot Spot on the Interleukin‐2 Surface
Author(s) -
Berg Thorsten
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400054
Subject(s) - tethering , small molecule , chemistry , biophysics , hot spot (computer programming) , surface protein , microbiology and biotechnology , nanotechnology , biochemistry , biology , computer science , materials science , virology , operating system
Get into the groove . Despite the absence of an obvious binding pocket in the surface of interleukin‐2, a small molecule has been discovered that “digs” itself into the protein surface and thereby inhibits an important protein–protein interaction. This Highlight discusses the discovery of the inhibitor by a fragment‐assembly method referred to as “tethering”. (Graphic reprinted with permission from ref. [4]. Copyright 2003 American Chemical Society)