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Synthesis and Phenotypic Screening of a Guanine‐Mimetic Library
Author(s) -
Miller Stephen C.,
Mitchison Timothy J.
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200400039
Subject(s) - guanine , phenotype , fluorescence microscope , phenotypic screening , chemistry , biochemistry , fluorescence , combinatorial chemistry , microbiology and biotechnology , biology , nucleotide , gene , physics , quantum mechanics
Going for guanine . We have synthesized a split‐pool library of guanine‐mimetics. Phenotypic screening of this library in mammalian tissue culture cells by fluorescence microscopy revealed several unique bioactive compounds, see scheme.