Engineered Biosynthesis of Phenyl‐Substituted Polyketides | Zendy

GarciaBernardo José | Zendy; Xiang Longkuan | Zendy; Hong Hui | Zendy; Moore Bradley S. | Zendy; Leadlay Peter F. | Zendy

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Engineered Biosynthesis of Phenyl‐Substituted Polyketides

Author(s) -

GarciaBernardo José,

Xiang Longkuan,

Hong Hui,

Moore Bradley S.,

Leadlay Peter F.

Publication year - 2004

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200400007

Subject(s) - polyketide , polyketide synthase , biosynthesis , biochemistry , phenylalanine ammonia lyase , dna ligase , primer (cosmetics) , phenylalanine , chemistry , biology , gene , amino acid , organic chemistry

Polyketide derivatives , such as 1 , are obtained in enhanced yield from added benzoate by coexpressing in Saccharopolyspora erythraea a hybrid erythromycin–soraphen polyketide synthase (PKS) together with benzoate:CoA ligase from the enterocin‐producing ( enc ) pathway of a marine streptomycete. Remarkably, coexpression of the single gene encP encoding phenylalanine ammonia lyase is sufficient to produce the PKS primer benzoyl‐CoA in S. erythraea from endogenous L ‐phenylalanine without any need to supply precursors in the medium.

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