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Patterns of DNA‐Labeled and scFv‐Antibody‐Carrying Lipid Vesicles Directed by Material‐Specific Immobilization of DNA and Supported Lipid Bilayer Formation on an Au/SiO 2 Template
Author(s) -
Svedhem Sofia,
Pfeiffer Indriati,
Larsson Charlotte,
Wingren Christer,
Borrebaeck Carl,
Höök Fredrik
Publication year - 2003
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200390055
Subject(s) - vesicle , lipid bilayer , dna , chemistry , bilayer , biophysics , fluorescence , liposome , biochemistry , membrane , biology , physics , quantum mechanics
Spots before the eyes: A material‐specific surface modification protocol was developed to allow surface‐directed immobilization of DNA‐labeled lipid vesicles. The potential of similarly immobilized vesicles to act as carriers for water‐soluble or transmembrane proteins in, for example, protein‐chip applications was demonstrated. The picture shows how fluorescent vesicles labeled with different DNA strands have been directed to one of two complementary‐DNA‐modified Au spots surrounded by an inert supported lipid bilayer on SiO 2 .