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Chemical Chaperones—A New Concept in Drug Research
Author(s) -
Kolter Thomas,
Wendeler Michaela
Publication year - 2003
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200390045
Subject(s) - chemical chaperone , fabry disease , drug discovery , drug , disease , chemistry , co chaperone , computational biology , biochemistry , pharmacology , medicine , biology , unfolded protein response , hsp90 , heat shock protein , endoplasmic reticulum , gene
A stabilizing influence: D ‐Galactose and the nojirimycin derivatives 1 and 2 have been successfully applied as “chemical chaperones” in therapy models of Fabry's disease and Gaucher's disease, respectively. These compounds illustrate the concept of specific low‐molecular‐weight chemical chaperones for the treatment of metabolic disorders.