Modelling of Photointermediates Suggests a Mechanism of the Flip of the  β ‐Ionone Moiety of the Retinylidene Chromophore in the Rhodopsin Photocascade | Zendy

Ishiguro Masaji | Zendy; Hirano Takahiro | Zendy; Oyama Yoshiaki | Zendy

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Modelling of Photointermediates Suggests a Mechanism of the Flip of the β ‐Ionone Moiety of the Retinylidene Chromophore in the Rhodopsin Photocascade

Author(s) -

Ishiguro Masaji,

Hirano Takahiro,

Oyama Yoshiaki

Publication year - 2003

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200390037

Subject(s) - chromophore , moiety , rhodopsin , steric effects , ionone , chemistry , flip , stereochemistry , double bond , molecular dynamics , retinaldehyde , photochemistry , computational chemistry , retinal , organic chemistry , apoptosis , biochemistry

Flip out! A model of the bathorhodopsin chromophore (see scheme) generated by molecular dynamics simulation suggests a twisted conformation of the C11C12 bond caused by steric interaction between the 13‐methyl group and Cys183. The twisted double bond may be involved in the flip of the β ‐ionone moiety toward transmembrane segments 3 and 4 in the formation of lumirhodopsin.

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