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Modulated Nucleoside Kinases as Tools to Improve the Activation of Therapeutic Nucleoside Analogues
Author(s) -
Monnerjahn Christian,
Konrad Manfred
Publication year - 2003
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200390024
Subject(s) - nucleoside , nucleoside analogue , kinase , enzyme , chemistry , pharmacology , biochemistry , biology
The use of nucleoside analogues in anticancer and antiviral treatments is often impaired by the slow intracellular activation of these drugs. This problem can be addressed by the modulation of rate‐limiting enzymes in the activation pathways of the nucleoside analogues. Therapeutic strategies based on the combination of optimized activating enzymes and established nucleoside drugs promise significant improvements to traditional chemotherapy.