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Use of Fluorine in the Medicinal Chemistry and Chemical Biology of Bioactive Compounds—A Case Study on Fluorinated Taxane Anticancer Agents
Author(s) -
Ojima Iwao
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300844
Subject(s) - taxane , chemical biology , prodrug , chemistry , fluorine , nanotechnology , combinatorial chemistry , organic chemistry , biochemistry , biology , materials science , cancer , genetics , breast cancer
Flurinated prodrugs . This minireview describes the exploitation of the unique nature of fluorine in the medicinal chemistry and chemical biology of taxane anticancer agents as a showcase in this field of research.